Tyler Moore

Dr. Tyler Moore

Associate Professor of Biology, College of Science and Technology

Email: tyler.moore@bellevue.edu
Twitter:  @DrTMoore

Education:
Postdoctoral Fellowship-Retroviral Immunology, National Institute of Allergy and Infectious Disease, National Institutes of Health (Hasenkrug Lab)

PhD Microbiology and Molecular Biology, University of Nebraska-Lincoln (Brown and Petro Labs)

B.S. Biology, University of Nebraska-Lincoln

Courses Taught:
Introduction to Biological Systems, Anatomy and Physiology, Genetics and Cellular Biology, Biological Investigation (I, II, III), Zoology, Developmental Biology, Immunology

Other:
Faculty sponsor of the Pre-Health Professionals Organization (contact if interested)

President of Green Bellevue Board (2023- ) (contact if you are interested in getting involved in environmental initiatives in the Bellevue area)

Teaching Philosophy: 

Science is not a collection of facts, but the process of addressing our curiosities about the natural world.  I am very interested in helping students learn to ask questions and explore the process of science concurrently with the content of each course.  I want you to learn how to become a scientist yourself, not just learn what other scientists have discovered.

Research Interests:

Innate Antiviral Signaling Pathways

Immune responses are important for controlling virus infection, but they can also cause damage to healthy tissues. We are interested in how our cells recognize viruses, determine the magnitude of the response, and terminate the immune response when the infection is cleared. See this post over a recent publication: New Mechanism of Controlling Antiviral Immune Responses.

Urban Plant Community Ecosystems

I am also interested in the ecology of interactions between plants and invertebrates. We are currently using our new 10,000 square foot native plant meadow to study how native plants contribute to campus biodiversity and to study adaptations of invertebrates in this natural setting.

We also have an ongoing collaboration with Dr. John Kyndt to study microbial changes in the soil of urban community as a result of changing land management (native plant landscapes compared to turf grass, for instance).

All research utilizes biology undergraduate students. Students will learn molecular biology, field biology, computational biology and coding, data analysis, and scientific writing when working on projects.

See the undergraduate research opportunities page for more.

Publications:

(bolded names indicate undergraduate co-authors)

Freed SM, Baldi DS, Snow JA, Athen SR, Guinn ZP, Pinkerton TS, Petro TM, Moore TC. MEK/ERK MAP kinase limits poly I:C-induced antiviral gene expression in RAW264.7 macrophages by reducing interferon-beta expression. FEBS Lett. 2021 Nov;595(21):2665-2674. doi: 10.1002/1873-3468.14200. Epub 2021 Oct 11. PMID: 34591979.
Soll F, Ternent C, Berry IM, Kumari D, Moore TC. Quercetin Inhibits Proliferation and Induces Apoptosis of B16 Melanoma Cells In Vitro. Assay Drug Dev Technol. 2020 Aug/Sep;18(6):261-268. doi: 10.1089/adt.2020.993. Epub 2020 Aug 14. PMID: 32799543.

Moore TC, Hasenkrug KJ. B-Cell Control of Regulatory T Cells in Friend Virus Infection. J Mol Biol. 2021 Jan 8;433(1):166583. doi: 10.1016/j.jmb.2020.06.022. Epub 2020 Jun 26. PMID: 32598936.

Kyndt JA, Moore TC. Draft Whole-Genome Sequence of a Novel Chryseobacterium viscerum Strain Isolated from Fresh Water at Dripping Springs, New Mexico. Microbiol Resour Announc. 2019 Oct 10;8(41):e01155-19. doi: 10.1128/MRA.01155-19. PMID: 31601674; PMCID: PMC6787331.

Moore, T.C., Messer, R.J., Gonzaga, L.M., Mather, J.M., Carmody, A.B., Bayer, W., Littwitz-Salomon, E., Dittmer, E., Hasenkrug, K.J. (2019). Effects of Friend Virus Infection and Regulatory T cells on the Antigen Presentation Function of B cells. mBio. 10(1):e02578-18.

Moore, T.C., Messer, R.J., Hasenkrug, K.J. (2018). Regulatory T cells suppress virus-specific antibody responses to Friend retrovirus infection. PLoS ONE. 13(4):e0195402.

Moore, T.C., Gonzaga, L.M., Mather, J.M., Messer, R.J., Hasenkrug, K.J. (2017) B cell Requirement for Robust Regulatory T cell Responses to Friend Virus Infection. mBio. 8(4):e01122-17.

Van Dis, E.S., Moore, T.C., Lavender, K.J., Messer, R.J., Keppler, O.T., Verheyen, J., Dittmer, U., Hasenkrug, K.J. (2016). No SEVI-mediated enhancement of rectal HIV-1 transmission of HIV-1 in two humanized mouse cohorts. Virology. 488(1):88-95.

Hargarten, J.C., Moore, T.C., Petro, T.M., Nickerson, K.M., Atkin, A.L. (2015). Candida albicans quorum sensing molecules stimulate mouse macrophage migration. Infect Immun. 83(10):3857-64. (Spotlight article)

Moore, T.C., Vogel, A.M., Petro, T.M., and Brown, D.M. (2015). IRF3 deficiency impacts granzyme B expression and maintenance of memory T cell function in response to viral infection. Microbes Infect. 17(6):426-39.

Moore, T.C. and Petro, T.M. (2014). Interferon response factor 3 is crucial to poly-I:C induced NK cell activity and control of B16 melanoma growth. Cancer letters. 361(1):122-128.

Moore, T.C., Cody, L., Kumm, P., Brown, D.M. , and Petro, T.M. (2013). IRF3 helps control acute TMEV infection through IL-6 expression but contributes to acute hippocampus damage following TMEV infection. Virus Research. 178(2):226-233.

Moore, T.C. and Petro, T.M. (2013). IRF3 and ERK MAP-kinases control nitric oxide production from macrophages in response to poly I:C. FEBS letters. 587(18):3014–3020.

Moore, T.C., Bush, K.L., Cody, L., Brown, D.M., and Petro, T.M. (2012). Interleukin-6 control of early Theiler’s Murine Encephalomyelitis Virus replication in macrophages occurs in conjunction with STAT1 activation and nitric oxide production. J. Virol. 86(19):10841-10851.

Moore, T.C., Al-Salleeh, F.M., Brown, D.M., and Petro, T.M. (2011). IRF3 polymorphisms induce different innate anti-Theiler’s virus immune responses in RAW264.7 macrophages. Virology. 418(1):40- 48.

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