Dr. Tyler Moore
Assistant Professor of Biology, College of Science and Technology
Postdoctoral Fellowship-Retroviral Immunology, National Institute of Allergy and Infectious Disease, National Institutes of Health (Hasenkrug Lab)
PhD Microbiology and Molecular Biology, University of Nebraska-Lincoln (Brown and Petro Labs)
B.S. Biology, University of Nebraska-Lincoln
Introduction to Biological Systems, Anatomy and Physiology, Genetics and Cellular Biology, Biological Investigation (I, II, III), Zoology, Developmental Biology, Immunology
Faculty sponsor of the Pre-Health Professionals Organization (contact if interested)
Science is not a collection of facts, but the process of addressing our curiosities about the natural world. I am very interested in helping students learn to ask questions and explore the process of science concurrently with the content of each course. I want you to learn how to become a scientist yourself, not just learn what other scientists have discovered.
I am interested in how our cells can recognize viruses and respond to them with appropriate signals. Some of these signals can overlap or conflict with other cellular signals, such as “survival” or “proliferation” signals. My students have studied antiviral signaling mechanisms that lead to protection from infection and cancer resistance.
I am also interested in the signaling pathways that control the developmental decisions of organisms. For instance, what signals tell a worm whether to produce an egg or to self-fertilize and generate a small worm through “live-birth.”
See the undergraduate research opportunities page for more.
Moore, T.C., Messer, R.J., Gonzaga, L.M., Mather, J.M., Carmody, A.B., Bayer, W., Littwitz-Salomon, E., Dittmer, E., Hasenkrug, K.J. (2019). Effects of Friend Virus Infection and Regulatory T cells on the Antigen Presentation Function of B cells. mBio. 10(1):e02578-18.
Moore, T.C., Messer, R.J., Hasenkrug, K.J. (2018). Regulatory T cells suppress virus-specific antibody responses to Friend retrovirus infection. PLoS ONE. 13(4):e0195402.
Moore, T.C., Gonzaga, L.M., Mather, J.M., Messer, R.J., Hasenkrug, K.J. (2017) B cell Requirement for Robust Regulatory T cell Responses to Friend Virus Infection. mBio. 8(4):e01122-17.
Van Dis, E.S., Moore, T.C., Lavender, K.J., Messer, R.J., Keppler, O.T., Verheyen, J., Dittmer, U., Hasenkrug, K.J. (2016). No SEVI-mediated enhancement of rectal HIV-1 transmission of HIV-1 in two humanized mouse cohorts. Virology. 488(1):88-95.
Hargarten, J.C., Moore, T.C., Petro, T.M., Nickerson, K.M., Atkin, A.L. (2015). Candida albicans quorum sensing molecules stimulate mouse macrophage migration. Infect Immun. 83(10):3857-64. (Spotlight article)
Moore, T.C., Vogel, A.M., Petro, T.M., and Brown, D.M. (2015). IRF3 deficiency impacts granzyme B expression and maintenance of memory T cell function in response to viral infection. Microbes Infect. 17(6):426-39.
Moore, T.C. and Petro, T.M. (2014). Interferon response factor 3 is crucial to poly-I:C induced NK cell activity and control of B16 melanoma growth. Cancer letters. 361(1):122-128.
Moore, T.C., Cody, L., Kumm, P., Brown, D.M. , and Petro, T.M. (2013). IRF3 helps control acute TMEV infection through IL-6 expression but contributes to acute hippocampus damage following TMEV infection. Virus Research. 178(2):226-233.
Moore, T.C. and Petro, T.M. (2013). IRF3 and ERK MAP-kinases control nitric oxide production from macrophages in response to poly I:C. FEBS letters. 587(18):3014–3020.
Moore, T.C., Bush, K.L., Cody, L., Brown, D.M., and Petro, T.M. (2012). Interleukin-6 control of early Theiler’s Murine Encephalomyelitis Virus replication in macrophages occurs in conjunction with STAT1 activation and nitric oxide production. J. Virol. 86(19):10841-10851.
Moore, T.C., Al-Salleeh, F.M., Brown, D.M., and Petro, T.M. (2011). IRF3 polymorphisms induce different innate anti-Theiler’s virus immune responses in RAW264.7 macrophages. Virology. 418(1):40- 48.